- More Information
Natural Stacks CILTEP Nootropic Stack - 60 capsules
CILTEP naturally increases focus and improves memory by inducing Long-Term Potentiation.
Long-Term Potentiation (LTP) is a long lasting enhancement in signal transmission between two neurons that results from stimulating them both at the same time. LTP is one of the major cellular mechanisms behind learning and memory. Memories are formed or “encoded” in the brain by creating LTP.
CILTEP achieves LTP by: 1 Inhibiting Phosphodiesterase-4 (PDE4), and 2 Increasing cyclic adenosine monophosphate (cAMP).
PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. Inhibition of PDE4 blocks the breakdown of cAMP, thereby increasing levels of cAMP within brain cells. PDE4 Inhibitors have been shown to have significant nootropic effects including increased cognition, improved long term memory, increased wakefulness, and neuroprotection.
Artichoke Extract is the safest and most effective PDE4 Inhibitor. There are other herbal supplements that can also perform PDE4 Inhibition but they have all been found to have significant side effects. CILTEP has 900 mg of the highest quality Artichoke Extract in each serving.
An herbal supplement named Forskolin (active compound extracted from the root of the Coleus Forskohlii plant) is the only known supplement to naturally increase cAMP levels. It activates the enzyme adenylyl cyclase which then increases intracellular levels of cAMP. CILTEP features premium Coleus Forskohlii standardized for 20% Forskolin. There are 4 mg of Forskolin in each serving of CILTEP.
Increasing cAMP and inhibiting its degradation (through PDE4 Inhibition) induces Long-Term Potentiation (LTP). The result is a significant overall improvement in cognitive function, especially memory formation and retention of new information.
Summary: PDE4 Inhibition + Increasing cAMP → LTP → Learning and Memory
CILTEP & NEUROTRANSMITTERS
CILTEP makes normal dopamine metabolism more effective at triggering the motivation, learning, and memory processes. Meanwhile the chemical dynamics of the dopamine system are preserved, avoiding the negative side effects associated with using traditional dopamine stimulation (such as is found in prescription stimulants).
Research has shown that increased intracellular cAMP increases the rate of dopamine and acetylcholine synthesis. L-Phenylalanine, L-Carnitine, and Vitamin B6 are included in the CILTEP formula to maintain optimal neurotransmitter levels.
L-Phenylalanine and L-Carnitine are amino acids found in some foods that the brain uses to make dopamine and acetylcholine. These natural nutrients synergise perfectly with Artichoke Extract and Forskolin, preventing fatigue and creating long lasting results with a lift in mood.
Suggested Use: For optimal mental performance, take a serving of 2-3 capsules immediately upon waking on an empty stomach. Do not take more than 3 capsules per day.
CILTEP can be taken daily, however we advise taking 1-2 days off per week (weekends for example).
U.S.A manufactured in a GMP facility. Natural Stacks proudly uses only the highest quality ingredients.
CILTEP is protected under U.S. Patent 9,149,547
Artichoke Extract contains Luteolin which is a natural inhibitor of the enzyme PDE4. This enzyme is present in neurons where it breaks down CREB activating cAMP. CREB activation is important for long-term potentiation, a process vital to learning and memory. Inhibiting PDE4 and thus increasing cAMP levels in neurons has been shown to increase long-term potentiation.
Forskolin is derived from the plant Coleus forskohlii and is used in traditional Indian Ayurvedic medicine. It has the property of increasing levels of cAMP in cells. Combined with Luteolin from Artichoke extract, forskolin synergistically increases the duration and levels of cAMP in neurons.
L-Phenylalanine is an essential amino acid present in many foods. When CREB is activated studies have shown that transcription of the enzyme tyrosine hydroxylase is increased leading to an increased rate of dopamine metabolism . L-Phenylalanine is the natural precursor to dopamine and thus helps supply the necessary amino acid fuel for that metabolism.
ALCAR is an acetylated form of the amino acid L-Carnitine. L-Carnitine is present in many foods but can also be synthesized in the liver. L-Carnitine increases mitochondrial energy production, helps burn fat and combats brain fatigue. We added ALCAR to the CILTEP stack to help mitigate the effects of "brain fatigue" so you can enjoy all day focus and productivity with no crash.
Vitamin B6 is an essential vitamin and an important enzymatic cofactor that helps the body produce essential neurotransmitters including dopamine, serotonin, and GABA. It helps activate DOPA decarboxylase, an enzyme directly downstream from tyrosine hydroxylase in dopamine metabolism and thus helps to maintain optimal dopamine metabolism under conditions of increased Tyrosine Hydroxylase that occur during CREB enhanced LTP.
- Delivery Info
The Evolution Organics offices will be closed on Friday the 14th and Monday the 17th of April 2017. These days are also not classed as 'working days' when referencing delivery times.
Fast and reliable shipping for the UK and Europe! All parcels tracked.
All products marked as in stock really are in stock here in the UK (at our offices just outside of Oxford) with the exception of:
- Tribest homeware - Due to the weight, these are dispatched directly by the distributor, usually on a next working day service. Please note, due to the weight, Tribest products can only be dispatched to the UK.
- LiveWheatgrass products. These are sent direct from the manufacturer as they are sent in dry-ice packaging ensuring that they keep cool during delivery.
All orders placed before 2.30pm Monday to Friday will be dispatched the same day. Orders placed after 2.30pm will be dispatched on the following working day. Please take this into account when viewing the services offered.
*Working day - where a 'working day' is referred to, this relates to Monday to Friday inclusive with the exception of UK national Bank Holidays
UK deliery service options
5 Working day*. Your order will be dispatched on the next available dispatch time (see above). Your order will be delivered by Royal Mail and can take up to 5 working days on a tracked service.
Express. Your order will be dispatched on the next available dispatch time (see above). Your order will be sent with the ParcelForce 24 service which aims to be delivered on the next working day*. On almost all occassions your order will be delivered within this time frame however, very rarely, but sometimes, the package may be delayed due to circumstances out of our control.
Express 12. As per the Express option, but to be delivered before 12pm.
Our delivery charges depend on where you'd like us to send your purchase, and how much it weighs. When you get to the basket page, we'll ask you where you'd like us to deliver to; we'll then show you how much your delivery charge will be.
UK delivery charges
(Excludes postcodes starting: HS,IV,KA,KW,PA,PH,ZE,BT,IM,TR)
Orders over £100
Cost (inc VAT)
All Express Free All Express before 12pm £4.00
Orders over £50
Cost (inc VAT)
All 5 working days Free All Express £3.00 All Express before 12pm £7.00
Orders under £50
Cost (inc VAT)
All 5 working days £3.00 All Express £6.00 All Express before 12pm £10.00
Highlands and Islands, Northern Ireland, Isle of Man, the Isles of Scilly and Channel Islands
(HS, IV, KA, KW, PA, PH, ZE,BT,IM,TR)
Free delivery on orders over £250
Cost (inc VAT)
Less than 2kg 5 working days £3.00 2kg or more 5 working days £11.75
Country Free shipping? Shipping cost (inc VAT) Austria On orders over £500 £24.00 Belgium On orders over £300 £15.00 Bulgaria £48.00 Canary Islands £39.00 Croatia £40.00 Cyprus £37.00 Czech Republic On orders over £500 £25.00 Denmark On orders over £300 £17.00 Estonia £39.00 Finland £32.00 France On orders over £300 £17.00 Germany On orders over £300 £17.00 Greece £42.00 Hungary £33.00 Ireland On orders over £250 £11.75 Italy On orders over £500 £25.00 Latvia £39.00 Lithuania £39.00 Luxembourg On orders over £300 £15.00 Malta £38.00 Monaco £35.00 Netherlands On orders over £300 £15.00 Norway £32.00 Poland £31.00 Portugal On orders over £500 £30.00 Romania £48.00 Slovakia £39.00 Slovenia £39.00 Spain On orders over £500 £30.00 Sweden £31.00 Switzerland On orders over 500 £25.00
We do our very best to recycle cardboard boxes and loosefill packing from our suppliers. As a rule, Evolution Organic now only buys loose fill packing chips made of corn starch which is 100% biodegradable which is why it is suitable for composting or can simply be thrown in the waste bin without doing harm to the environment. The manufacturing process for corn starch loose fill is low in energy consumption and demands no chemical agents, only water.
- Returns Information
Evolution Organics Return Policy
We very much hope you will be pleased with your purchase. Should you wish to return anything bought from us, we will be happy to refund or exchange a product provided if it is in fully resalable condition for up to 14 days.
DISTANCE SELLING REGULATION
Right of withdrawal - You have the right to withdraw from the sale contract within 14 days without giving any reason. The withdrawal/cancellation period will expire: after 14 days from the day on which you acquire physical possession of the products.
To exercise the right of withdrawal/cancellation, you must inform us of your decision to cancel this contract by a clear statement (by post, email or phone call).
Effects of cancellation - If you withdraw from this contract, we will reimburse to you all payments received from you, including the cost of delivery when the item was sent to you.
We will make the reimbursement using the same means of payment as you used for the initial transaction, you will not incur any fees as a result of the reimbursement.
YOU MUST let us know before you send anything as we might be able to arrange this for you. Unless specified, DO NOT send the good via any other way than 1st/2nd class post (DO NOT USE "signed for", "registered", "next day" or any other courier). If you need to use a courier please let us know!
North Wing, The Stables
Products we are unable to refund or exchange:
We are unable to offer a refund or exchange on any nutritional products if they have been opened unless they are faulty in some way. We are also unable to offer refunds after 14 days. *Please see the note above on the Distance Selling Regulations.
How long will it take to receive a refund from returned products?
Refunds will usually reach your account within 7-14 working days. Timing will, however, depend on the speed with which your credit/debit card company processes the credit. In some cases, we might send you a cheque for the item(s) returned if the amount has already been processed by our bank.
Thanks very much
Evolution Organics team
- Can We Help
Can we help?
For further information or to place an order please feel free to contact our team.
Our opening hours are:
Monday to Thursday 9.30am to 5.00pm
Friday 9.30am to 4.30pm
Live online Chat: please use the link at the bottom of the page.
- Calls from within the UK & Mobiles: 0345 3700 006
- International Calls: 0044 1865 880214
If you want to send something to us:
North Wing, The Stables
Core Evolution Limited also trading as Evolution Organics
Company No: 5037677 VAT Registration Number: 831300578